100 questions with answersProvisional keyKannada Date of Test : 22-05-2023

Assistant Professor in Pharmacy - Medical Education question paper 2023

Date of test: 22-05-2023
Question paper code: 34/2023/OL
Category No.: 561/2017
Questions: 100
Answer key: Provisional Answer Key
Exam mode: Online (computer based)

Provisional key. Kerala PSC can change answers after reviewing complaints; the final key decides the marks.

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Source: Kerala PSC (keralapsc.gov.in) · official document· Last updated 25 Sept 2026· How we check content

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All 100 questions with answers

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1.
Modiﬁed Brontrager's test in Aloe is performed due to the presence of
Show answer and explanation
Answer: B —
C-glycoside
Modified Bornträger's test is used to detect C-glycosides present in Aloe.
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2.
The crude drug used as an anti hypertensive
Show answer and explanation
Answer: D —
Catechu
Catechu and certain other drugs have specific uses, though antihypertensive properties are associated in specific contexts.
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3.
The parameter of growth for assessing the relative contribution of cell aggregates and free cells to growth in culture medium is
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Answer: C —
Mitotic index
Mitotic index is used to assess the relative contribution of cell aggregates and free cells to growth.
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4.
Indian liquorice is the other name of
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Answer: B —
Abrus precatorius
Abrus precatorius is commonly known as Indian liquorice.
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5.
The gene transfer method which is not suitable for protoplasts
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Answer: A —
Biolistic method
Biolistic method is generally not suitable for protoplasts due to high shear forces.
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6.
Cycloeudesmol an antibiotic substance is isolated from
Show answer and explanation
Answer: D —
Red algae
Cycloeudesmol is isolated from red algae.
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7.
Ash value is used to detect the following except
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Answer: C —
Decomposed products
Ash values help identify adulteration, low grade products, exhausted drugs, and excess earthy matter.
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8.
Forskolin, used in treatment of cardiomyopathy is a
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Answer: A —
Diterpene
Forskolin is a labdane diterpene.
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9.
Formation of lignin compounds is by
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Answer: C —
Shikimic acid pathway
Lignin compounds are synthesized via the shikimic acid pathway.
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10.
The plant growth regulator which act as selective weedicide or herbicide in high concentrations
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Answer: B —
Auxins
Auxins act as selective weedicides/herbicides at high concentrations (e.g., 2,4-D).
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11.
Who is proved existence of receptors ?
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Answer: B —
James Langly
Question cancelled in the final key.
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12.
Lysosomes are unit membrane bound organelles that contain
Show answer and explanation
Answer: C —
Acid hydrolase
Lysosomes contain acid hydrolases enzymes.
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13.
The most primitive cell in erythropoiesis
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Answer: A —
Pluripotent stem cell
Pluripotent stem cell is the most primitive cell giving rise to all blood cells including erythrocytes.
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14.
Which vitamin is needed for synthesis of collagen, the main bone protein ?
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Answer: A —
Vitamin C
Vitamin C is essential for the hydroxylation of proline and lysine in collagen synthesis.
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15.
Which of the following is inhibitory neuro transmitter ?
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Answer: D —
Glycine
Question cancelled in the final key.
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16.
At the point where the trachea divides in to right and left primary bronchi, an internal ridge called
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Answer: B —
Carina
The internal ridge at the tracheal bifurcation is called the carina.
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17.
Oestrogen act on
Show answer and explanation
Answer: C —
Nuclear receptor
Estrogen acts via intracellular nuclear receptors.
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18.
T ype I anaphylactic reactions, anaphylaxis is mediated by
Show answer and explanation
Answer: C —
IgE antibodies
Type I hypersensitivity reactions are mediated by IgE antibodies.
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19.
The position of Dose response curve, on the dose axis is the index of
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Answer: D —
Drug potency
Potency is indicated by the position of the dose-response curve along the dose axis.
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20.
Drug which undergoes enterohepatic cycling
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Answer: C —
Oral contraceptives
Oral contraceptives undergo enterohepatic circulation.
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21.
Name the partial agonist effective for smoking cessation.
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Answer: C —
Verenicline
Varenicline is a partial agonist of the $\alpha_4\beta_2$ nicotinic acetylcholine receptor used for smoking cessation.
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22.
Benzodiazepine antagonist
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Answer: D —
Flumazenil
Flumazenil is a competitive antagonist at the benzodiazepine binding site on the $GABA_A$ receptor.
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23.
Teicoplanin belongs to
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Answer: D —
Glycopeptides
Teicoplanin is a glycopeptide antibiotic similar to vancomycin.
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24.
Name one luminal amoebicide
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Answer: A —
Diloxanide furoate
Diloxanide furoate acts in the lumen of the bowel as an amoebicide.
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25.
Azole antifungal agent active against Mucor mycosis
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Answer: B —
Posaconazole
Posaconazole is active against mucormycosis among the azole antifungals.
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26.
Selective adrenoceptor antagonists
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Answer: D —
Tamsulosin
Tamsulosin is a selective $\alpha_{1A}$ adrenoceptor antagonist.
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27.
A macrolide antibiotic with significant activity against Mycobacterium leprae
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Answer: C —
Clarithromycin
Clarithromycin has demonstrated significant activity against Mycobacterium leprae.
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28.
Purine antimetabolite with cytotoxic and immunosuppressant action
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Answer: A —
Azathioprine
Azathioprine is a purine antimetabolite widely used as an immunosuppressant.
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29.
Aminoglycoside antibiotic having resistance to bacterial aminoglycoside modifying enzyme
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Answer: D —
Amikacin
Amikacin is structurally modified to resist many aminoglycoside-inactivating enzymes.
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30.
Raltegravir is
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Answer: B —
Integrase inhibitor
Raltegravir is an HIV integrase strand transfer inhibitor.
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31.
In XYZ classification for inventory control the drugs are categorized on their
Show answer and explanation
Answer: A —
High, low and intermediate inventory values
XYZ analysis categorizes inventory based on the inventory value (high, medium, low value).
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32.
Which method is a useful tool in overall analysis of cost volume relationship in charging policy ?
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Answer: C —
Break-even point pricing
Break-even point pricing is used to determine the point where total revenue equals total costs, helping in cost-volume analysis.
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33.
LDH3 the enzyme mainly concentrated in which tissue ?
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Answer: B —
Lungs
LDH3 isoenzyme is primarily found in the lungs.
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34.
Pramlintide belongs to which class of drug ?
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Answer: A —
Amylin analogue
Pramlintide is a synthetic analogue of the hormone amylin used in diabetes management.
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35.
Trachoma is caused by which organism ?
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Answer: D —
Chlamydia trachomatis
Trachoma is an infectious eye disease caused by the bacterium Chlamydia trachomatis.
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36.
One step dry chemistry method can be used to measure
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Answer: A —
Concentration of drugs in the body
Dry chemistry methods are often used for rapid point-of-care testing, including drug concentration monitoring.
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37.
Name the place where the first drug information centre is established.
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Answer: B —
University of Kentucky
The first drug information center was established at the University of Kentucky in 1962.
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38.
What does Urea breath test for ?
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Answer: D —
To examine the presence of H. Pylori
The urea breath test is a diagnostic test used to detect the presence of Helicobacter pylori in the stomach.
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39.
Anti-CCP is the biological Marker for which disease ?
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Answer: D —
Rheumatoid Arthritis
Anti-cyclic citrullinated peptide (Anti-CCP) antibodies are highly specific markers for Rheumatoid Arthritis.
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40.
Which is the method used for sterilization of thermo labile powders ?
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Answer: A —
Gaseous sterilization
Gaseous sterilization (e.g., Ethylene oxide) is suitable for heat-sensitive (thermo-labile) materials.
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41.
In gradient elution technique
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Answer: B —
Two solvents that are completely miscible in each other and with different dielectric constant is used
Gradient elution involves changing the composition of the mobile phase over time to improve separation.
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42.
The absorption maxima of 1, 4-dimethylcyohex-1, 3-diene using Woodward-Fieser rule is
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Answer: A —
273 nm
Based on Woodward-Fieser rules for dienes, the calculated value is 273 nm.
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43.
Ferroin indicator is
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Answer: B —
Orthophenanthroline-ferrous complex
Ferroin is the complex of 1,10-phenanthroline with ferrous ions.
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44.
In infrared spectroscopy, for preparing solid samples, the solid sample is mixed with Nujol to a thick paste in
Show answer and explanation
Answer: B —
Mull technique
The mull technique involves grinding the sample with a mulling agent like Nujol to create a paste.
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45.
Which of the following statement is false about Mohr's method of titration ?
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Answer: B —
The solution to be titrated should be acidic
Mohr's method must be performed at a neutral or slightly alkaline pH (6.5-9.0) because chromate ions react in acidic conditions.
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46.
Ilkovic equation gives the relationship between
Show answer and explanation
Answer: B —
Diffusion current vs concentration
The Ilkovic equation relates the diffusion current to the concentration of the electroactive species in polarography.
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47.
Give the relative areas of multiplets of methylene protons in the proton NMR spectra of
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Answer: B —
1 : 3 : 3 : 1
The relative intensities of multiplets follow Pascal's triangle; for a quartet (n=3), it is 1:3:3:1.
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48.
The molecular ion peak of methylene chloride in the mass spectrum will be at the m/z value
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Answer: A —
84
Methylene chloride ( $CH_2Cl_2$ ) has a molecular weight of approximately $12 + 2 + (35.5 \times 2) = 85$ . The peak at 84/86 corresponds to the isotopes of chlorine.
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49.
Fourier transform NMR instruments records
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Answer: B —
Free induction decay signal
FT-NMR records the Free Induction Decay (FID) signal, which is then converted to a spectrum via Fourier transform.
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50.
If the organic samples are contaminated with water and oxides of nitrogen and sulphur, the detector of choice in gas chromatography is
Show answer and explanation
Answer: A —
Flame ionization detector
Flame Ionization Detector (FID) is highly sensitive to hydrocarbons and is generally unaffected by water and common inorganic gases.
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51.
The co-enzyme not involved in hydrogen transfer
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Answer: D —
FH4
FH4 (Tetrahydrofolate) is primarily involved in one-carbon unit transfer, not hydrogen transfer.
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52.
Recombinant enzyme used for the treatment of Pompe disease is
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Answer: A —
$\alpha$ -glucosidase
Pompe disease is treated with enzyme replacement therapy using recombinant human $\alpha$ -glucosidase.
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53.
Example of Amino acid containing thioether group
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Answer: B —
Methionine
Methionine contains a thioether group in its side chain.
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54.
Isomerism exhibited by unsaturated fatty acids
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Answer: C —
Both 1 and 2
Unsaturated fatty acids can exhibit both geometric (cis/trans) isomerism due to double bonds and optical isomerism if chiral centers are present.
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55.
As per induced fit theory for enzyme substrate complex formation
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Answer: A —
The active site is not rigid and pre-shaped
According to the induced fit model, the active site is flexible and molds around the substrate upon binding.
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56.
Measurement of lowering of vapour pressure can be done by
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Answer: D —
All the above
All listed methods are standard techniques used to measure the lowering of vapour pressure of solutions.
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57.
Pick out the correct order of stability of carbocation relative to the substrate from which it is formed.
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Answer: B —
Tertiary > Secondary > Primary
Carbocation stability increases with alkyl substitution due to hyperconjugation and inductive effects (Tertiary > Secondary > Primary).
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58.
Cobalt labelled cyanocobalamin is used in the
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Answer: C —
Both 1 and 2
Cobalt-labeled cyanocobalamin (Vitamin B12) is used in the Schilling test for diagnosing pernicious anemia.
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59.
Which of the following statement is true about amines ?
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Answer: A —
Primary amines undergo carbylamine reaction
Only primary amines (both aliphatic and aromatic) react with chloroform and alcoholic KOH to form foul-smelling carbylamines (isocyanides).
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60.
Pyridine is less basic than aliphatic amines because the lone pair of electrons on N-atom in pyridine is in
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Answer: B —
$sp^2$ hybrid orbital
The nitrogen atom in pyridine is $sp^2$ hybridized, holding the lone pair in an $sp^2$ orbital which has more s-character, holding electrons more tightly than an $sp^3$ orbital.
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61.
Colterol is a
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Answer: A —
Selective $\beta_2$ -agonist
Colterol is a selective $\beta_2$ adrenergic receptor agonist.
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62.
What happens when the substitution on the amino nitrogen in adrenergic agonists increase in size from hydrogen to methyl to isopropyl ?
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Answer: B —
$\alpha$ receptor agonist activity decreases and $\beta$ -receptor agonist activity increases
Increasing the bulk of the alkyl substituent on the amino nitrogen increases $\beta$ -receptor selectivity and activity while decreasing $\alpha$ -receptor activity.
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63.
Give an example of imidazopyridine derivative used as a hypnotic.
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Answer: C —
Zolpidem
Zolpidem is an imidazopyridine derivative widely used as a sedative-hypnotic.
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64.
The drug Meperidine should not be administered to patients receiving
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Answer: A —
Monoamine oxidase (MAO) inhibitor
Co-administration of meperidine with MAO inhibitors can lead to severe, potentially fatal reactions including serotonin syndrome.
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65.
Which of the following is an $\alpha$ -Glucosidase inhibitor used as hypoglycemic agent ?
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Answer: C —
Both 1 and 2
Acarbose, voglibose, and miglitol are all well-known $\alpha$ -glucosidase inhibitors used in diabetes management.
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66.
Hammett substituent constant
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Answer: D —
All the above
The Hammett constant ( $\sigma$ ) quantifies the electronic (inductive and resonance) effects of substituents at meta and para positions on aromatic rings.
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67.
Which of the following is the pro-drug of pralidoxime ?
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Answer: A —
Pro-2-PAM
Pro-2-PAM is lipophilic prodrug designed to enhance the penetration of pralidoxime across the blood-brain barrier.
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68.
IUPAC name of Ketamine is
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Answer: A —
2-(2-Chlorophenyl)-2-(methylamino) cyclohexanone
Ketamine is chemically known as 2-(2-chlorophenyl)-2-(methylamino)cyclohexanone.
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69.
Synthesis of Phenytoin from benzil takes place via
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Answer: B —
Benzilic acid rearrangement
The synthesis of phenytoin from benzil and urea proceeds via a mechanism analogous to the benzilic acid rearrangement.
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70.
Example of an iminostilbene derivative used as anticovulsant
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Answer: A —
Carbamazepine
Carbamazepine is a dibenzazepine (iminostilbene) derivative widely prescribed as an anticonvulsant and mood stabilizer.
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71.
For a new drug substance intended for storage in a refrigerator, the long term stability studies as per ICH guidelines are to be conducted at a storage temperature of
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Answer: A —
$5 \pm 3^\circ C$
According to ICH guidelines, for drugs stored in a refrigerator, long-term stability testing is conducted at $5 \pm 3^\circ C$ .
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72.
Pick out the wrong statement.
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Answer: D —
Different areas within a manufacturing plant requires the same SOP (Standard Operating Procedure) for cleaning
Cleaning SOPs are area-specific and equipment-specific, not uniform across all areas of a plant.
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73.
With an increase in temperature, surface tension of water
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Answer: B —
Decreases
Surface tension generally decreases as temperature increases because the kinetic energy of molecules increases, reducing cohesive forces.
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74.
Pick out the correct statement
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Answer: B —
Colloidal particles can pass through a filter paper
Colloidal particles are small enough to pass through ordinary filter paper but are retained by semipermeable membranes.
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75.
Which among the following has the highest HLB value ?
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Answer: C —
Sodium lauryl sulphate
Sodium lauryl sulphate is an ionic surfactant with a very high HLB value (typically around 40), making it highly hydrophilic.
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76.
Which among the following can be used for the determination of viscosity of a Newtonian liquid ?
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Answer: D —
All the above
All listed viscometers can be used to measure the viscosity of Newtonian liquids.
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77.
The shelf life of a drug (assuming duration of retaining at least 90% of initial strength as shelf life) undergoing first order decomposition can be calculated using the formula
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Answer: B —
0.104 divided by rate constant for decomposition
For first-order kinetics, $t_{90} = \frac{0.105}{k} \approx \frac{0.104}{k}$ .
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78.
In a Fisher sub sieve sizer,
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Answer: C —
Surface area of a powder is determined by air permeability method
The Fisher sub-sieve sizer determines the average particle size of a powder based on the air permeability principle.
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79.
Who among the following is not an ex officio member of the Drugs Technical Advisory Board ?
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Answer: D —
Minister of Chemicals and Fertilizers, Govt. of India
The Minister of Chemicals and Fertilizers is not an ex officio member of the DTAB.
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80.
The chairman of Drug Enquiry Committee constituted in 1930
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Answer: A —
Col. R.N. Chopra
The Drug Enquiry Committee (1930) was chaired by Col. R.N. Chopra.
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81.
The Bacterial strain used for manufacture of BCG vaccine
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Answer: B —
Attenuated live strain of Mycobacterium Bovis
BCG vaccine is prepared from an attenuated live strain of Mycobacterium bovis.
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82.
The active ingredient present in Dettol solution
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Answer: A —
Chloroxylenol
Chloroxylenol is the primary active antiseptic ingredient in Dettol.
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83.
The pore size of millipore filter GS grade used for aseptic processing
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Answer: A —
$0.22 \pm 0.02 \mu m$
GS grade Millipore filters typically have a pore size of $0.22 \mu m$ , which is standard for sterile filtration.
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84.
During sterility testing, the inactivating agent used for inhibiting agents like phenol and alcohol is
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Answer: B —
Dilution
Dilution is a common method used to reduce the concentration of inhibitory substances like phenol or alcohol below their toxic levels during sterility testing.
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85.
The solvent used inside the boilable catgat tube is
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Answer: C —
Toluene
Toluene is used as the storage fluid in boilable catgut tubes to maintain the flexibility of the suture.
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86.
The first FDA approved monoclonal antibody used to treat organ transplant rejection
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Answer: C —
Muromonab-CD3
Muromonab-CD3 (Orthoclone OKT3) was the first monoclonal antibody approved by the FDA for clinical use in preventing organ transplant rejection.
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87.
Which of the following route of drug administration cannot be considered as extravascular ?
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Answer: C —
Intraarterial
Intraarterial administration is a vascular route, whereas intramuscular, subcutaneous, and sublingual are extravascular routes.
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88.
Which among the following class of drugs is having the highest apparent volume of distribution ?
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Answer: D —
Amphetamines
Amphetamines are lipophilic basic drugs that extensively distribute into tissues, resulting in a large apparent volume of distribution.
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89.
Which of the following options is showing the rate of metabolism as defined by Michaelis-Menten equation ?
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Answer: B —
\frac{V_{max} \cdot C}{K_m + C}
The Michaelis-Menten rate expression is $\frac{V_{max} C}{K_m + C}$ .
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90.
For drugs that are not systematically absorbed like antacids, bioequilivalence studies is carried out by
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Answer: A —
A surrogate marker with pharmacodynamic effect
For locally acting, non-absorbed drugs, pharmacodynamic endpoints or surrogate clinical markers are used.
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91.
Which one of the following dryer is known as lyophilizer ?
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Answer: B —
Freeze dryer
Freeze dryers are also known as lyophilizers.
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92.
What are the modes observed in a ball mill for size reduction ?
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Answer: A —
Impact and attrition
Ball mills reduce particle size primarily through impact (tumbling balls) and attrition (sliding/rubbing).
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93.
Which one of the distillation method is used to get sharp separation between component of the mixtures containing miscible volatile liquid having different but close boiling point ?
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Answer: A —
Rectification
Rectification (fractional distillation) provides sharp separation of miscible volatile liquids with close boiling points.
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94.
Which one of the mixing equipment used for two immiscible liquids ?
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Answer: C —
Silverson mixer emulsifier
Silverson mixer emulsifiers are high-shear mixers used for blending immiscible liquids to form emulsions.
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95.
During compression, air entrapment may lead to
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Answer: B —
Capping and laminating
Trapped air in tablet granulations during high-speed compression causes capping and lamination upon decompression.
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96.
Pyrogens are
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Answer: B —
Bacterial Endotoxins
Pharmaceutical pyrogens are principally lipopolysaccharide bacterial endotoxins from Gram-negative bacteria.
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97.
What are the characteristics of the mixed monolithic reservoir devices ?
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Answer: C —
Drug polymer matrix is layered by rate controlling membrane
In mixed monolithic reservoir systems, a drug core/matrix is enclosed by a rate-controlling polymeric membrane.
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98.
The 00 size capsules can fill the volume of
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Answer: D —
0.95 ml
Size 00 hard gelatin capsules have a nominal fluid volume capacity of approximately 0.95 mL.
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99.
Hepta fluoro propane is
Show answer and explanation
Answer: D —
Propellent 227
HFA 227 (heptafluoropropane) is designated as propellant 227.
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100.
Treated soda lime glass is called as
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Answer: C —
Type II
Type II glass consists of soda-lime glass treated with sulfur dioxide to neutralize surface alkalinity.
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